Not had a chance to try this yet, but there are folks out there already trying to use the Wii remote for their own invention. Fortunately, its a straightforward bluetooth device and the communication seems to be unencrypted, so some people such as those behind Darwiin-remote have begun creating drivers and software to let you use the controller on other platforms (in this case OSX). It seems IR pointing and motion (accelerometer) are already supported. Makes for a very cheap mouse for presentations or installations

Download Darwiin-remote here.